Peptide Inhibitor Of Complement C1 Modulates Acute Intravascular Hemolysis...
Acute hemolytic transfusion reactions have a broad clinical presentation from mild and transitory signs and symptoms to shock, disseminated intravascular...
Read MoreComplement Effectors Of Inflammation In Cystic Fibrosis Lung Fluid...
In cystic fibrosis (CF), lung damage is mediated by a cycle of obstruction, infection, and inflammation. Here we explored complement...
Read MorePeptide Inhibitor of Complement C1 (PIC1) Rapidly Inhibits Complement...
The complement system has been increasingly recognized to play a pivotal role in a variety of inflammatory and autoimmune diseases....
Read MorePeptide Inhibitor Of Complement C1, A Novel Suppressor Of...
The classical pathway of complement plays multiple physiological roles including modulating immunological effectors initiated by adaptive immune responses and an...
Read MoreComplement inhibition significantly decreases red blood cell lysis in...
Background: Prevention of acute hemolytic transfusion reactions is a worldwide concern. The objective of this study was to develop a...
Read MoreClinical Hypothermia Temperatures Increase Complement Activation And Cell Destruction...
Therapeutic hypothermia is a treatment modality that is increasingly used to improve clinical neurological outcomes for ischemia-reperfusion injury-mediated diseases. Antibody-initiated...
Read MoreA Novel Peptide Inhibitor Of Classical And Lectin Complement...
Previous experiments from our laboratories have identified peptides derived from the human astrovirus coat protein (CP) that bind C1q and...
Read MorePotent Inhibition Of The Classical Pathway Of Complement By...
Previous work from our laboratories has demonstrated that purified, recombinant human astrovirus coat protein (HAstV CP) binds C1q and mannose-binding...
Read MoreHuman astrovirus coat protein binds C1q and MBL and...
Human astroviruses (HAstVs) constitute a family of non-enveloped, RNA viruses which cause infantile gastroenteritis. We have previously demonstrated that purified...
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