Pipeline

ReAlta’s pipeline is focused on advancing novel therapeutics for severe inflammatory diseases with significant unmet need.
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Pegtarazimod
Status
Preclinical
Phase 1
Phase 2
Phase 3
Notes
Hypoxic Ischemic Encephalopathy (HIE) peds-IV
Ongoing
HIE: Phase 2 interim data available for discussion under CDA
Other indications
novel formulation
In Progress
GVHD
adult-IV
Completed
Completed Phase 2 proof-of-concept data support pegtarazimod’s activity in an inflammatory disease setting.
Exacerbations
of COPD
adult-IV
Completed
Completed Phase 2 proof-of-concept data support pegtarazimod’s activity in an exacerbation setting.

Distinctive Features of the Innovative Peptide Design of Pegtarazimod

Tissue
penetration

Molecular size (~2.7KDa) and amphipathic character of ReAlta’s peptides enable efficient tissue penetration

MOAs

Simultaneous and independent inhibition of complement and neutrophil effectors at the most destructive stages of the inflammatory cascade

Blood brain
barrier

Small molecular size enables ReAlta’s peptides to cross an intact blood-brain barrier

No off-target
toxicity

No off-target effects as ReAlta’s peptides exert their activity extracellularly

No
immunogenicity

Proprietary peptides do not generate anti-drug antibodies

Flexible
admin routes

Multiple routes of administration