News Release

November 16, 2021

MPO Data Presented at ACR 2021

Myeloperoxidase activity in individuals with Anti-neutrophil cytoplasmic antibodies (ANCA) can be inhibited by RLS-0071

At the 2021 Annual Conference of Rheumatology (ACR), Dr. Parvathi Kumar, ReAlta’s Associate Director of Early Clinical Development, presented data demonstrating that lead compound RLS-0071 inhibits myeloperoxidase activity in individuals with anti-neutrophil cytoplasmic antibodies (ANCA).

RLS-0071 is a PEGylated peptide which inhibits MPO activity in animal models and ex vivo and also inhibits neutrophil mediated NETosis in vitro and in vivo.

ReAlta conducted a pilot study measuring MPO activity in patient samples acquired commercially from a biorepository.  AI (Antibody Index) units were available for each sample which represents a manufacturer specific composite score of anti-MPO, anti-PR3 and anti-GBM antibody titers.

In this pilot study, ReAlta’s researchers found that plasma from ANCA patients demonstrated a wide range of MPO activity and the AI unit appears to generally trend with plasma MPO activity. We also demonstrated that RLS-0071 inhibits MPO activity in plasma acquired from individuals with ANCA-associated pathophysiology. Future studies will focus on elucidating relationships between MPO activity, MPO quantity, free plasma DNA as a surrogate measurement of NETs and anti-MPO titers.

More information about the American College of Rheumatology can be found at this link.


Feb 16, 2021

ReAlta Life Sciences Doses First Subject In Phase 1 Healthy Volunteers Study...

Norfolk, VA, February 16, 2021 – ReAlta Life Sciences, Inc. (“ReAlta”), a company addressing life-threatening diseases through harnessing the power...

Read More
Dec 03, 2020

ReAlta Life Sciences Announces EMA Orphan Drug Designation for RLS-0071 For The...

Norfolk, VA, December 3, 2020 — ReAlta Life Sciences, Inc., today announced that the European Medicines Agency (EMA) has granted Orphan...

Read More
Nov 19, 2020

ReAlta Life Sciences Featured In Norfolk Innovation Corridor, Launch Of New Technology...

Norfolk, VA, November 19, 2020 — Norfolk, Virginia, known globally for its expertise in resilience and strong entrepreneurship ecosystem, is...

Read More