Our Science

Genesis of the EPICC Platform

Genesis Of The EPICC Platform
WHAT

EPICC molecules are derived from a human enteric virus that has adapted over 1 billion years of evolution. The viral capsids are composed of a simple structure of 180 copies of a single protein consisting of 787 amino acids. This virus does not generate immune responses and possesses a unique dual targeting mechanism inhibiting humoral and cellular inflammation.

HOW

Peptides derived from this capsid protein maintain both the humoral and cellular immune inhibition activity of the virus. The EPICC technology is built on a library of more than 150 of these dual action peptides.

WHY

Therapies derived from viruses have been a source of Nobel prize winning scientific advancements and discoveries. Many drugs currently on the market are derived from natural sources, such as antibiotics.

Scientists

EPICC Platform And Our Unique Dual Targeting Mechanisms Of Action

The EPICC platform presents a novel opportunity to modify disease progression through moderation of the most robust components of both humoral (complement system) and cellular (neutrophils) components of innate immunity.

FIRST TARGET

Complement
Pathway

EPICC molecules rapidly and dose dependently inhibit C1 and MBL, the earliest initiators of the classical and lectin complement pathway. Inhibition is via transformational changes of serine proteases at C1 and MBL.

  • Selective upstream targeting of the complement system increases selectivity, efficacy, and reduces adverse events.

  • EPICC molecules do not interfere with C1q homeostatic functions and preserve the alternative pathway, maintaining the body’s immunosurveillance capacity.

  • EPICC molecules’ small size and function lead to excellent tissue penetration.

Complement Pathway
SECOND TARGET
Inhibiting Innate Inflammatory Processes

In addition to complement modulation, the EPICC platform acts as a potent inhibitor of innate, neutrophil-mediated, inflammatory processes, including inhibition of MPO activity and NETosis.

  • Blocks MPO activity which generates hypochlorous acid and host tissue injury.

  • Inhibits NETosis, a neutrophil death pathway contributing to host tissue damage.

  • Exhibits anti-oxidative properties and neutralizes free radicals in the body.

Mpo Activity
Inhibiting MPO Activity

MPO catalyzes formation of hypochlorous acid and tyrosyl radicals, and is released by neutrophils and innate immune cells, contributing to inflammation.

Inhibition of NETosis
Inhibition of NETosis

EPICC molecules’ cysteine-rich region modulates the peroxidase activity of MPO, blocking hypochlorous acid formation and preventing neutrophil extracellular trap (NET) formation.

Anti Oxidative
Anti-Oxidative Processes

The EPICC platform’s cysteine-rich region inhibits the SET and HAT mechanisms of oxidant damage to tissues at equivalent potency as glutathione, the main antioxidant in humans.

Safety Profile

Our lead compound of RLS-0071 has an excellent safety profile to date, with toxicity testing demonstrating no side effects in two animal species treated with large doses of RLS-0071. We have completed a study in Healthy Volunteers, RLS-0071-101, and will share safety findings under confidentiality. These findings will also be reported out at a medical conference in early 2022.

Scientific Review and Support

RLS-0071 has had widespread scientific review and support. Scientists conducting research on RLS-0071 capabilities have published 25 peer-reviewed and indexed studies. A number of leading research organizations, including the NIH, National Multiple Sclerosis Foundation, Cystic Fibrosis Foundation, VA Catalyst and the Commonwealth Transfusion Foundation have provided grant funding to ReAlta.