Hypoxic Ischemic Encephalopathy

Based on results from the “gold standard” HIE animal model, RLS-0071 decreases the area of brain infraction by 50% and dramatically improves neurocognitive outcomes, even to adult age. As seen below, there is little visible difference between the normal rat pup brain and the brain of a rat treated with RLS-0071, while untreated rats and rats treated with hypothermia show large areas of dead brain tissue.

Normal BrainNormal Brain
HIE + HypothermiaHIE + Hypothermia
HIE + RLS-0071HIE + RLS-0071

RLS-0071 also dramatically improves neurocognitive function of HIE-induced rats. Below are test results of rat ability to remember escape hole locations. HIE-induced rats treated with RLS-0071 are clearly smarter.

Hypoxia + Ligation Hypoxia +
Hypoxia + Ligation + Hypothermia Hypoxia +
Ligation +
Hypoxia + Ligation + RLS-0071 Hypoxia +
Ligation +

There are currently no pharmaceutical approaches to treat birth asphyxia. RLS-0071 is the first anti-inflammatory/antioxidant compound studied for HIE. As such, RLS-0071 represents a new treatment approach with a focus on preventing brain damage. RLS-0071 is designed to decrease reperfusion injury via our dual targeting mechanisms of action that inhibits complement activation and innate inflammatory processes and oxidative damage.


These MRI findings were recently published in a PLoS article, which can be found at this link.

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