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Hypoxic Ischemic Encephalopathy

Based on results from the “gold standard” HIE animal model, RLS-0071 decreases the area of brain infraction by 50% and dramatically improves neurocognitive outcomes, even to adult age. As seen below, there is little visible difference between the normal rat pup brain and the brain of a rat treated with RLS-0071, while untreated rats and rats treated with hypothermia show large areas of dead brain tissue.

Normal BrainNormal Brain
HIEHIE
HIE + HypothermiaHIE + Hypothermia
HIE + RLS-0071HIE + RLS-0071

RLS-0071 also dramatically improves neurocognitive function of HIE-induced rats. Below are test results of rat ability to remember escape hole locations. HIE-induced rats treated with RLS-0071 are clearly smarter.

Hypoxia + Ligation Hypoxia +
Ligation
Hypoxia + Ligation + Hypothermia Hypoxia +
Ligation +
Hypothermia
Hypoxia + Ligation + RLS-0071 Hypoxia +
Ligation +
RLS-0071

There are currently no pharmaceutical approaches to treat birth asphyxia. RLS-0071 is the first anti-inflammatory/antioxidant compound studied for HIE. As such, RLS-0071 represents a new treatment approach with a focus on preventing brain damage. RLS-0071 is designed to decrease reperfusion injury via our dual targeting mechanisms of action that inhibits complement activation and innate inflammatory processes and oxidative damage.

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